Abstract
Thallium-201 myocardial perfusion imaging with dipyridamole was performed on 85 patients with suspected coronary artery disease (CAD). Twentyeight patients had normal coronary arteries (control group) and 57 patients had 50% or greater stenosis in one or more of the major coronary arteries (CAD group). In the control group, aminophylline was infused intravenously in 12 patients during dipyridamole testing. The mean washout rate (WR) of these 12 patients was faster than that of the 16 patients without aminophylline (42 vs. 34%, p < 0.01). Then, normal limits of WR were defined separately from the patients in the control group with and without aminophylline. The diagnostic accuracy in the detection of individual diseased coronary arteries by WR analysis, for which normal limits of WR were determined from all patients in the control group, was 64% (110/171). When the normal limits were calculated separately with and without aminophylline, the diagnostic accuracy increased to 76% (130/171, p < 0 .05). Aminophylline affected the myocardial washout of thallium-201 after dipyridamole infusion. Specific sets of normal limits obtained with and without aminophylline are required for the accurate evaluation of WR in CAD patients.
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