Abstract
Summary The purpose of this study was to assess the effects of intravenous administration of d -tubocurarine and pancuronium in fetal lambs. Eighteen experiments were performed in seven chronically instrumented pregnant ewes between 0.8 and 0.9 of timed gestation. Each fetus received 6 ml of study drug intravenously at 1.2 ml/min over 5 minutes ( d -tubocurarine 3.0 mg/kg, pancuronium 0.5 mg/kg, or saline solution control). Pancuronium ( n = 7) significantly increased both fetal heart rate and mean arterial pressure. d -Tubocurarine ( n = 5) significantly decreased both fetal heart rate and mean arterial pressure. Saline solution control ( n = 6) did not significantly alter fetal heart rate or mean arterial pressure. The present study suggests that pancuronium is preferable to d -tubocurarine for those intrauterine procedures when an increase in fetal heart rate is desired. (Am J Obstet Gynecol 1989;160:510-3.)
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