Abstract
In this report the case of intravascular large B-cell lymphoma (angiotropic lymphoma, intravascular angioendotheliomatosis, malignant endotheliomatosis) with panniculitis features is present. The diagnosis was based on finding of typical CD20 positive tumorous cells within capillaries, veins, and small arteries in the biopsy of subcutaneous adipose tissue. An accurate and early diagnosis together with combined chemotherapy resulted in good response and remission of the disease.
Highlights
Intravascular large B-cell lymphoma, known as intravascular angioendotheliomatosis or malignant endotheliomatosis, is characterized by widespread intravascular proliferation of malignant lymphoid cells in capillaries, venules, arterioles, and small arteries [7,5]
Intravascular large B-cell lymphoma was subsequently diagnosed on the base of skin biopsy and the patient gave a good response to chemotherapy
Immunohistochemistry was carried out using monoclonal antibodies CD20 (DAKO, 1:100), CD45R0 (DAKO, 1:100), FVIII (DAKO, 1:100), CD31 (DAKO, 1:200), CD68 (DAKO, 1:100), and CD30 (DAKO, 1:25)
Summary
Intravascular large B-cell lymphoma, known as intravascular angioendotheliomatosis or malignant endotheliomatosis, is characterized by widespread intravascular proliferation of malignant lymphoid cells in capillaries, venules, arterioles, and small arteries [7,5]. The vasculature of the skin and central nervous system is most commonly affected, and the patients frequently present with cutaneous findings or neurologic symptoms. We describe a case of a patient with fever, elevated blood sedimentation rate, and migrating subcutaneous infiltrates of low extremities and breasts. Intravascular large B-cell lymphoma was subsequently diagnosed on the base of skin biopsy and the patient gave a good response to chemotherapy. Neous infiltrates of low extremities and breasts. Laboratory examination was performed together with mammography and biopsy of low extremity and breast infiltrates. Subsequent CT brain scan together with vertebral canal MRI revealed multiple small lesions
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