Abstract

PurposeRecent advances in endoscopy have led to new technologies with significant optical imaging improvements. Since its development a few years ago, narrow-band imaging (NBI) has already been proved useful in detecting malignant lesions and carcinoma in clinical settings of urology, gastroenterology and ENT. The potential of this technology for imaging applications of the arterial vessel wall has not been properly analysed yet, but with the observed benefits could prove valuable for this clinical use as well.MethodsIn order to assess the efficacy of NBI, defects such as burns and mechanical tears were created on the walls of an arterial vessel sample. Ex vivo imaging using NBI and white light imaging (WLI) were performed with rigid and flexible fibre endoscopes.ResultsA thorough comparison of the images proved that NBI enhances the visualisation of lesions and defects on the artery walls compared to normal WLI.ConclusionWLI provides a direct image of the vessel lumen and its anatomical shape. It is suitable for observation and documentation of intravascular therapies. NBI images are more distinct and have more contrast. This helps to detect even small defects or changes on the inner vessel wall that could provide additional information and lead to more precise and personalised therapies.

Highlights

  • We present a study on the feasibility of narrow-band imaging (NBI) in intraarterial wall visualisation and compare the acquired images with those obtained using conventional white light imaging (WLI) endoscopy and microscopy

  • NBI showed an increase of intensity gradients of 22% in average, leading to the visible enhancement of the structure in NBI compared to WLI

  • The feasibility of NBI compared to WLI in an ex vivo intravascular setting was tested

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Summary

Methods

The tests were done in our catheter laboratories (INKA— Intelligent Catheter, OVGU, Magdeburg). In order to make the comparison, certain conditions had to be created on the tissue samples to simulate mechanical and thermal ablation defects, or inflammations. Scalpels were used to create small mechanical defects on the inner tissue surface to simulate dissections. A tissue holder was created based on a 50-ml syringe, tube connectors and plugs for sealing (Fig. 1). The sample for the final test was a fresh extracted portion of the iliac artery obtained from a swine. It was kept in blood after extraction because the presence of haemoglobin inside the tissue is necessary for NBI imaging. The rigid 4-mm endoscope was inserted into the sample and imaging using WLI and NBI was performed. The average of intensity change was computed and compared for WLI and NBI

Results
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Compliance with ethical standards
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