Abstract

Intravascular coagulation is a characteristic feature of the hemorrhagic state associated with acute promyelocytic leukemia. Hypofibrinogenemia and reduced levels of prothrombin and of Factors V, IX, and X in a child with acute stem cell leukemia were treated successfully with heparin despite the existence of thrombocytopenia. The diagnostic criteria of this unusual bleeding syndrome, the kinetic nature of the problem, the occurrence of intravascular coagulation in leukemia, and treatment with heparin are discussed.

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