Abstract
Increased rates of catabolism of 125I-labelled fibrinogen were found in six patients with acute hepatic necrosis. In these and in a further seven patients a fall of other coagulation factors and platelets was associated with increased fibrinolysis. These findings suggest that severe necrosis of liver cells causes increased intravascular coagulation. The accelerated utilisation of clotting factors, at a time when their synthesis is reduced by liver damage, would contribute to the high incidence of bleeding in this condition. Treatment with heparin lowered the rate of fibrinogen catabolism to normal.
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