Abstract
To the Editor: Intravascular irradiation effectively reduces neointimal proliferation after coronary interventions. Scheinert et al1 showed that vasoconstriction is a frequent reaction of coronary arteries after high-dose intracoronary β-radiation, necessitating repetitive administration of vasodilators. Unfortunately, these authors did not study the effects of β-radiation on the microcirculation and small resistance vessels. To examine the acute effects of intravascular β-irradiation on the coronary collateral blood flow, we studied 7 patients with stable angina, 4 with in-stent restenosis, and 3 with de novo lesions while they were undergoing angioplasty and intracoronary β-irradiation. Eight control patients, 2 with in-stent restenosis and 6 with de novo lesions, underwent balloon angioplasty without intracoronary β-irradiation. All patients underwent a minimum …
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