Abstract
The effect of intravas device placement on the adrenergic innervation of the vas deferens was studied in the rabbit. Utilizing varying methods for intravas device insertion (non-transected vs. transected vas), segments of vasa were removed at autopsy and examined histologically for the fluorescent histochemical demonstration of norepinephrine. In each surgical procedure, fluorescence was maintained above the device site or area of transection. Intraluminal placement of an intravas device without vas transection reduced, but did not abolish, innervation below the device site; fluorescence below the device was abolished, however, if the vasa were transected. Comparative studies with vasectomized rabbits resulted in a similar loss of fluorescence below the area of transection.It is concluded that transection of the rabbit vas deferens for intravas device insertion results in a loss of adrenergic innervation below the point of transection; this effect can be mimicked by vasectomy. Intravas device insertion without transection retained some of the neuromuscular integrity of the vas smooth musculature.
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