Intrauterine exposure to endocrine disruptors (phenols, parabens, triclosan and phthalates) & their influence on birth weight, SAMI cohort, Medellín - Colombia.

Abstract

Intrauterine exposure to endocrine disruptors (phenols, parabens, triclosan and phthalates) and their influence on birth weight, SAMI cohort, Medellín - Colombia.Introduction: recent scientific evidence questions intrauterine exposure to endocrine disruptors influences birth weight. Objective: to evaluate the influence of intrauterine exposure and endocrine disruptors (phenols, parabens, triclosan and phthalates) on birth weight. Methodology: the study has 2 phases. Phase I (epidemiological): cohort of 400 women ≤ 12 weeks of gestation which were measured 5 phenols, 5 parabens, triclosan, triclocarban and 16 phthalates in urine. By means of multiple linear regression, the correlation between exposure to endocrine disruptors and birth weight and the selection of regression coefficients (β) was selected, and by means of multiple binary logistic regression, the relationship in exposure to compounds Chemicals and the risk of low birth weight and related risks (RR) are presented. Phase II (In Vivo model), based on the particles found in pregnant women, is designed in an experimental model in mice where the effect of prenatal exposure to a mixture of endocrine disruptors (BPA, DEHP, BBP, DBP, DEP is evaluated) on outcomes at birth in the offspring of mice of the wild type C57BL / 6J strain and presents the media differences between the 4 groups. Conclusions: phase I: for each increase of ng / mL of BPA, MEPA, ETPA, OXBE, MnBP, MBzP, MEHP, DEHP, OH-MiNP and oxo-MiNP, the birth weight is reduced. In addition, high exposure to BPA, ETPA, TRCS, MiBP, MnBP, MBzP, MEHP and cx-MiNP increases the risk of low birth weight. Phase II: Prenatal exposure to a mixture of endocrine disruptors (BPA, DEHP, BBP, DBP, DEP) reduces gestation time and birth weight.