Abstract
Received August 26, 2014 Revised October 6, 2014 Accepted October 7, 2014 Address for correspondence Yong-Hwi An, MD Department of Otorhinolaryngology, Eulji Medical Center, Eulji University School of Medicine, 68 Hangeulbiseok-ro, Nowon-gu, Seoul 139-872, Korea Tel +82-2-970-8276 Fax +82-2-970-8275 E-mail an0072@hanmail.net Background and ObjectivesZZThe effectiveness of intratympanic dexamethasone injections (ITD) alone is compared against the combination therapy of ITD and oral diuretics as treatments for acute low frequency sensorineural hearing loss (LFHL) without vertigo. Subjects and MethodZZA total of 36 patients, with LFHL ≤500 Hz that had been developed within the last 1 month, were enrolled and then were retrospectively categorized into two groups: 1) those treated with ITD four times each day for 4 consecutive days (ITD only group; 19 patients) and 2) those treated with ITD in the same way and diuretics orally for 2 weeks (combination group; 17 patients). After 8 weeks, treatment outcomes were analyzed for LFHL using subjective improvement and audiometric change. ResultsZZHearing thresholds at low frequencies ≤500 Hz were significantly reduced at 8 weeks after treatment in both ITD only and combination group (p 0.05). For subjective symptoms, there were no statistically significant differences in the improvement rate in either group (combination 58.8% vs. ITD only 63.2%, p>0.05). In pure tone audiometry, the improvement rate of the combination group was not significantly different from that of the ITD only group (76.5% vs. 73.7%, p>0.05). There was a significant correlation between the complete recovery rate and duration of symptoms. ConclusionZZITD alone is an effective treatment modality for LFHL within 1 month after onset. Diuretics have no additive effect for the recovery of hearing in patients with acute LFHL without vertigo. Korean J Otorhinolaryngol-Head Neck Surg 2015;58(1):19-24
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