Intratumoural injection of gamma leinolenic acid in malignant gliomas

Abstract

In vitro and in vivo studies have shown that gamma-leinolenic acid (GLA) can selectively kill tumour cells without harming normal cells. In view of this we have investigated the effect of intratumoural injection of GLA in intracranial gliomas, after reconfirmation of the safety of the drug on normal dog brain ( n = 3). Fourteen patients underwent neurosurgical decompression along with placement of a catheter into the tumour bed. At the end of 1 week following surgery the patients were injected with 1 mg of GLA in sterile saline into the tumour bed daily for 10 days through the reservoir placed in the bone flap. Repeat computed tomography scans were obtained both before and after the GLA therapy with and without contrast administration. Necrosis and regression of the tumour have been observed, with reduction in mass effect and shift of midline structures. Two years' follow-up reveals that GLA is safe and tumour recurrence may be less in treated patients.