Abstract
The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation. Such a phenomenon has inspired us to apply the pro-oxidative mechanism of GA-Fe to anticancer therapy. In this work, we construct a composite cancer nanomedicine by loading gallate into a Fe-engineered mesoporous silica nanocarrier, which can degrade in acidic tumor to release the doped Fe3+ and the loaded gallate, forming GA-Fe nanocomplex in situ. The nanocomplex with a highly reductive ligand field can promote oxygen reduction reactions generating hydrogen peroxide. Moreover, the resultant two-electron oxidation form of GA-Fe is an excellent Fenton-like agent that can catalyze hydrogen peroxide decomposition into hydroxyl radical, finally triggering severe oxidative damage to tumors. Such a therapeutic approach by intratumoral synthesis of GA-Fe nano-metalchelate may be instructive to future anticancer researches.
Highlights
The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation
Transmission electron microscopy (TEM) image and selected area electron diffraction (SAED) pattern indicate that the as-prepared Mesoporous silica nanoparticles (MSNs) are monodispersed with an amorphous structure, (Supplementary Fig. 1), favoring subsequent preparation of Fe-HMSNs in a harsh hydrothermal basic condition, during which the –Si–O–Si– framework of MSN template gradually hydrolyzes into Si-containing oligomers such as orthosilicic acid (Si(OH)4) on the surface of MSNs
TEM images indicate that the as-prepared Fe-HMSNs are monodispersed with a uniform diameter of around 200 nm (Fig. 2b), which is further evidenced by dynamic light scattering (DLS) measurement (Supplementary Fig. 2)
Summary
The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation. The chelation of ferrous ions (Fe3+) by gallic acid (3,4,5-trihydroxybenzoic acid, GA) is the key chemical reaction for preparing iron gall ink, resulting in the formation of 3D iron-gallate (GA–Fe) metalchelate polymer with deep black color for using as writing/painting materials[2] Such an iron coordination compound is highly reductive that can reduce oxygen (O2) to superoxide anion (O2−) and hydrogen peroxide (H2O2), initiating subsequent Fenton-like reactions, especially in acidic environment that generate highly oxidizing hydroxyl radicals (OH), leading to the oxidation and degradation of cellulose in papers[3,4]. Cellular experiments and in vivo model further demonstrate the high anticancer efficacy of FHPG by intratumoral synthesis of iron gall nano-metalchelate, indicating the feasibility of such a catalytic therapeutic approach for future cancer therapy
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
