Abstract
Meeting abstracts The abscopal effect is a phenomenon that occurs when radiation of disease at one-site leads to regression of distant, untreated tumors. Historically, the abscopal effect caused by conventional radiation therapy has been rare. However, the combination of radiation and immunotherapy
Highlights
The abscopal effect is a phenomenon that occurs when radiation of disease at one-site leads to regression of distant, untreated tumors
The combination of radiation and immunotherapy has increased the reported incidence of this effect, which is thought to be mediated by an adaptive immune response
We have demonstrated that radiation alone (RT) is weakly effective at generating anti-tumor adaptive immune responses despite release of tumor-associated antigen
Summary
The abscopal effect is a phenomenon that occurs when radiation of disease at one-site leads to regression of distant, untreated tumors. Baird et al Journal for ImmunoTherapy of Cancer 2014, 2(Suppl 3):P158 http://www.immunotherapyofcancer.org/content/2/S3/P158 Intratumoral injection of STING ligand promotes abscopal effect
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