Abstract
The identity and distribution of amines in the calf thyroid was investigated by histochemistry and cytospectrofluorometry, and the possible significance of these amines in the synthesis of thyroid hormone was assessed by testing their influence on the uptake and organifkation of iodine in calf thyroid cells, dispersed by continuous-flow trypsinization. The calf thyroid was found to contain four different amine-storing cell systems: 1. Norepinephrine (NE) was present in sympathetic nerve fibres that were located both as a network around vessels and as single fibres running close to the follicles. 2. Dopamine (DA) and histamine (Hi) were demonstrated in mast cells that were numerous and occurred both in perifollicular and perivascular spaces. 3. DA was also found in parafollicular cells (C cells), which were relatively few. 4. Numerous acetylcholine-(ACh)-containing nerve fibres were seen around vessels and between follicles. Histochemical examinations of smears of thyroid cell suspensions revealed that, ap...
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