Abstract
Intraventricular therapy (IVT) with polymyxin B (PolyB), an antibiotic with similar pharmacological action to colistin (PolyE), by external ventricular derivation (EVD) has the main goal of offering major bioavailability of the drug, since its use by intravenous and direct action are restricted by the blood-brain barrier, with penetration of only 25%. Pseudomonas aeruginosa is a Gram-negative bacterium, multidrug resistant, which has a characteristic of secreting exotoxin A. Along with Acinetobacter baumannii, it has expressed a great risk to the lives of patients with meningoencephalitis. The patient of the present report had arterial venous malformations followed by hemorrhagic stroke, which caused elevated intracranial pressure. The objective is to show an example of the effect of IVT PolyB in a patient with meningoencephalitis infection by multidrug-resistant Gram-negative bacteria (A. baumannii and P. aeruginosa), common in the ICU.
Highlights
In this study we aimed to investigate the relationship between thyroid hormone abnormalities and major cardiovascular events and sudden cardiac death at 3 and 6 months after discharge in patients who were admitted to the Emergency Department with acute coronary syndrome
The aim of this study was to demonstrate the role of arginase and adenosine deaminase (ADA) in patients suffering from myocardial infarction (MI), and in a group of patients with chronic renal failure (CRF) with cardiovascular diseases (CVD)
ADA may be considered good diagnostic enzymes in patients suffering from MI, and ADA for patients with CRF with CVD
Summary
Results We studied 53 patients (42 males, mean age (SEM) 57.6 (2.8) years, illness severity scores APACHE II 21.3 (0.9); SAPS II 53.3 (2.3); SOFA 10.2 (0.2); and ICU stay 35.9 (4.8) days). Results We included 53 consecutive patients (42 males, mean age 57.6 ± 2.8 years, illness severity scores APACHE II 21.3 ± 0.9; SAPS II 53.3 ± 2.3; SOFA 10.2 ± 0.2; and mean ICU stay 35.9 ± 4.8 days) of which 25 (47.2%) had at least one US findings. The objective of this study was to determine the incidence and type of incidents related to intrahospital transport (IHT) of critically ill patients in our ICU and to identify contributing factors of these incidents. The aim of this study was to assess the effect of monotherapy with nebulized colistin on clinical and microbiological outcomes in critically ill patients with VAT due to polymyxin-only susceptible Gram-negative bacteria
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