Intrathecal hyaluronidase for impending and symptomatic arachnoiditis in Tubercular Meningitis

Abstract

CNS Tuberculosis, the most rampant infection of the developing world, clinicopathologically can occur alone or combined as Tubercular Meningitis, Tuberculomas (intracranial and/or spinal), Arachnoiditis (basal, optochaismatic, spinal) or Myelitis. The viscous exudates in basal cisterns cause Optochiasmatic arachnoiditis[1], and nodular, thickened, clumped nerve roots called Lumbosacral arachnoiditis.[2] We herein propose use of intrathecal hyaluronidase, as adjuvent for symptomatic as well as impending arachnoiditis.