Abstract
We report a case of meningitis caused by a multiresistant gram-negative rod that was successfully treated with intrathecal colistin. A 30-year-old boy who had a car accident required hospitalization, including decompressive craniectomy and placement of an external ventricular drainage catheter. Cerebrospinal fluid and blood cultures demonstrated Acinetobacter spp. Intravenous colistin was initiated initially but there was no change in the patient's clinical situation. Therapy was added to intrathecal colistin 5 mg/day via the external ventricular drainage catheter, and cerebrospinal fluid cultures were followed to assess efficacy. Our experience shows that intrathecal colistin is a safe and curative treatment drug for multidrug-resistant Acinetobacter spp menengitis.
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