Intrathecal clonidine versus intrathecal midazolam with hyperbaric bupivacaine for post operative analgesia in abdominal hysterectomy

Abstract

Objectives: This randomised study was conducted to compare the effects of intrathecal clonidine and midazolam with hyperbaric bupivacaine for post operative analgesia in patients undergoing abdominal hysterectomy. Materials and Methods: 60 patients of ages between 40 and 60 years of ASA grade I/II undergoing abdominal hysterectomy were randomly divided into two equal groups. Group C and group M received 0.5% hyperbaric bupivacaine 3ml with either clonidine 45µg with 0.2 ml saline or midazolam 2.5mg respectively intrathecally. Onset and duration of sensory blockade, haemodynamic changes, duration of post operative analgesia, number of rescue analgesics and side effects if any, were observed. Results: There was statistically significant difference in the onset and duration of sensory block (p<0.001) between the two groups. Duration of post operative analgesia was significantly longer in midazolam group (373.33±24.22 minutes) than in clonidine group (328.5±21.78 minutes). Conclusion: Spinal anaesthesia with 2.5 mg midazolam as an adjuvant to 3ml hyperbaric bupivacaine provides longer duration of post operative analgesia compared to 45µg clonidine with 3ml hyperbaric bupivacaine with better haemodynamic stability without any adverse effects.