Abstract
Perinatal hypoxia/ischemia (H/I) is a brain disturbance due to the absence or decrease in oxygen supplementation in newborns, and represents a leading cause of neurologic injury. Neurological sequelae include cerebral palsy (CP), epilepsy, and cognitive deficit. The reparative, regenerative, and replicative properties of hematopoietic cells have shown that they could be a potential treatment of several neurological conditions, including chronic brain damage. It has been found that hematopoietic cells may be transported through the cerebrospinal fluid and be delivered more efficiently to the injured area after their introduction in the subarachnoid space of the spinal cord when compared with the intravenous route.
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