Abstract
THE neurologic manifestations of Central-nervous-system involvement in acute leukemia have been very well described.1 2 3 4 5 6 7 Although involvement of the brain is not rare7 , 8 greater emphasis has been placed on its occurrence in young children than in adults. This may well be related to the general view that children are more responsive to antileukemic therapy than adults9 and that their longer periods of survival may allow for the more frequent appearance of complications. Of particular interest is the fact that leukemic encephalopathy may develop in the face of complete hematologic remission, frequently in association with 6-mercaptopurine or antifolic acid therapy.10 This can . . .
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