Abstract
SummaryThe intratesticular injection of a single, 2 μg dose of NIH-FSH-S-2, was detectable histologically, in immature hypophysectomized rats, one day after the injection. FSH induced specific germ cell loss, Sertoli cell hypertrophy, and increased fluid secretion. Germ cell depletion was intensified after 3 days and following two, 2 μg FSH doses. After 5 days, during which time 2 μg FSH was given every other day, systemic absorption of the hormone was evidenced by germ cell loss in contralateral uninjected testes. Days 7 to 15 were histologically similar to day 5. The rapid early changes in germ cell population, and Sertoli cell stimulation following intratesticular injections of FSH in the immature hypophysectomized rat when contrasted with the control status of the uninjected contralateral testis, should provide a basis for a specific assay of this hormone.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
