Abstract
To evaluate the feasibility of intrastromal lenticule rotation (ISLR) as a novel technique for management of astigmatism up to 10.00 diopters (D). Eighteen human donor corneas were mounted on an artificial anterior chamber. After laser application and dissection, the lenticule was rotated 90° in the intrastromal pocket. Scheimpflug tomography (Pentacam HR; Oculus Optikgeräte GmbH, Wetzlar, Germany) was acquired preoperatively and following ISLR. The attempted astigmatic correction was twice the cylindrical magnitude of the lenticule referenced to the corneal plane: 4.80 D (5.00 D group, n = 9) and 9.32 D (10.00 D group, n = 9), respectively. The change in keratometric astigmatism was evaluated by vector analysis. In the 5.00 D group, ISLR caused a mean absolute surgical induced astigmatism (SIA) of 5.30 ± 1.14 D with a correction index (CI) of 1.14 ± 0.25 and an angle of error (AoE) of -0.80° ± 4.61°. In the 10.00 D group, the SIA averaged 9.57 ± 1.10 D with a CI of 1.03 ± 0.12 and an AoE of 2.75° ± 3.60°. The average total corneal refractive power (TCRP) increased 1.36 ± 0.67 and 1.95 ± 1.57 D in the 5.00 D and 10.00 D groups, respectively. Postoperative optical coherence tomography revealed stromal redistribution in the periphery of the optical zone with tissue addition in the preoperative steep meridian and tissue reduction in the preoperative flat meridian. ISLR seemed feasible and precise for management of regular astigmatism up to 10.00 D ex vivo in human donor corneas. A myopic shift was observed in TCRP. The in vivo corneal remodeling after ISLR warrants investigation. [J Refract Surg. 2019;35(7):451-458.].
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Schedule a callMore From: Journal of refractive surgery (Thorofare, N.J. : 1995)
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