Intraseptal microinjections of carbachol and angiotensin II in rats: Effects on taste preferences

Abstract

The present study examined the effects of carbachol and angiotensin II injected into the medial and lateral septal areas (MSA and LSA) on the ingestion of primary taste solutions in a free-choice situation. The injection of carbachol or angiotensin II into MSA and LSA of water sated rats evoked a preference for the sweet tasting saccharin solution and water. The lateral septal rats also preferred acetic acid solution. Only the total fluid intake differed significantly among the four groups. In the water deprived rats injection of chemical to the respective groups induced the ingestion of NaCl solution. The MSA rats on injection of carbachol also preferred saccharin apart from NaCl. There was a significant difference in the NaCl intake among the four groups. The quinine solution was not consumed by all the groups. These results indicate that both the carbachol and angiotensin II induce the ingestion of saccharin, NaCl and water. The MSA might be more sensitive in inducing NaCl intake as compared with LSA during deprivation schedule and cholinergic stimulation. The LSA also evokes a preference for the sour tasting acetic acid. Furthermore, the data also suggest that the neurons sensitive to angiotensin are more potent than cholinergic neurons of LSA in producing salt preference.