Intraretinal Cystoid Spaces in Regression of Punctate Inner Choroidopathy Lesions

Abstract

ABSTRACT Purpose To describe and evaluate the intraretinal cystoid spaces (ICSs) in the eyes of punctate inner choroidopathy (PIC) patients. Methods In this observational study, patients diagnosed with PIC were included and reviewed between December 2016 and November 2018. All patients underwent multimodal retinal imaging examinations. Results Forty-one eyes of 26 patients diagnosed with PIC were included. ICSs were found in 13 eyes (31.7%) of 11 subjects. Statistical analysis revealed that except for spherical equivalent (P= .020), there were no significant difference between patients with ICSs and those with no ICSs at baseline. There were two types of ICSs according to the multimodal imaging findings. These two types of ICSs appeared with regressive PIC lesion and were stable during the follow-up period. Conclusion ICSs are commonly observed in PIC and they may be a sign of the restoration stage of the disease rather than a need for further clinical intervention.