Abstract
Walker 256 tumours grafted under the left kidney capsules in rats showed enhanced growth following daily treatment with diazepam 500 μg (1.7 mg/kg body weight) subcutaneously but not with 1250 μg. Thromboxane B 2 (the metabolite of TXA 2) levels in venous drainage from both the tumour bearing left kidney and 2from the right control kidney were reduced significantly in all the three groups of tumour bearing rats. Plasma PGE 2 was higher in the venous drainage from the tumour bearing left kidney than from the right control kidney. Significantly higher levels were measured following 500 μg but not after 1250 μg of diazepam. Plasma PGF 2α on the other hand, was lower in the plasma from the tumour bearing kidney and was further lowered in animals receiving diazepam treatment.
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