Abstract
In the normal human kidney, the intrarenal tissue concentrations of ampicillin in the hydrated and hydropenic state demonstrate a pattern similar to that previously described for the kidney of the dog. The outer medullary and papillary concentrations, of presumed importance in the treatment of pyelonephritis, are uninfluenced by the state of hydration. In the severely diseased human kidney, a marked reduction in tissue penetration of the antibiotic is noted, and the ability of the kidney to concentrate ampicillin in the urine is greatly reduced. Levels in serum are almost twice as high as the levels in renal tissue. Studies of intrarenal distribution of ampicillin in the normal and diseased state should facilitate interpretation of tube-dilution studies in the management of complicated renal infections.
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