Abstract
Intrapulmonary connective tissue was studied in hysterectomy-produced colostrum-deprived (HPCD) pigs, germ-free pigs and pigs raised in a conventional manner. The histogenesis of lymphoreticular cell aggregates (synonym: lymphoid tissue) from primitive connective tissue cell aggregates was of special interest. Lymphoreticular cell aggregates were found with increasing frequency and amount ill HPCD pigs with increasing age. Lymphoreticular cell aggregates were more plentiful in lungs of conventionally reared pigs than in lungs of HPCD pigs of similar age. Lungs of germ-free pigs were free of these aggregates. Lymphoreticular cell aggregates were found at all levels of the bronchial and vascular divisions. The most consistent structural relationship was with pulmonary lymphatics.
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