Abstract
Due to the frequent use of intrapleural interleukin-2 (IL-2) to treat pleural effusions from malignant mesothelioma (MMe), we measured nitric oxide (NO) end product nitrite (NO 2 −) in pleural effusions of 12 MMe patients with chronic or chronic-relapsing pleurisy. Through high performance liquid chromatography analysis, NO 2 − was found in the initial pleural fluid sample of all patients (156.25 pmol ml −1), and increased significantly following IL-2 intrapleural instillation, both at 24 (589.91 pmol ml −1, P⩽0.0005) and 48 h (756 pmol ml −1, P⩽0.0005). Even though it is difficult to argue if the large amounts of NO end product NO 2 − we observed is produced by IL-2-stimulated and recruited immune cells, by MMe cells themselves, or by both, it is possible that NO could contribute to the complex antitumor activity of IL-2.
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