Abstract
In previous studies we have demonstrated that transplantation of fetal rat intestine into the peritoneal cavity of adult rats is possible and that the transplanted gut undergoes differentiation and maturation. Histology of these transplants showed normal appearance. In a further study we wanted to examine the functional integrity of the transplanted intestine after anastomosis to the intestine of the host. Disaccharidase activities were measured in the transplant and compared to the “control” activities found in the intestine of the host rat. Maltase and sucrase activities of the transplant were approximately 60% of control, lactase activity was the same for transplant and control. The capacities of glucose and amino acid uptake of the transplanted epithelium were not different from control. Peristalsis of the transplant was measured by electromyographic recordings: slow wave frequency and spike activity were at the same levels as in controls. These re-results demonstrate that the transplanted fetal rat intestine has the structural and functional characteristics of the normal rat small bowel and should be considered as an alternative to the transplantation of adult bowel. Supported by DFG Grant Ha 1402/1-1
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