Abstract
In recent years, many studies have found that mechanical tension can activiate NF-kB signal pathway and NF-kB plays an important role in the process of osteogenesis. However, it is still unclear whether this process exists in the anterior palatal suture expansion. In this paper, we mainly studied the effect of intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis index of the anterior palatal suture expansion model in young adult rats. The expansion model is grouped and established: 45 male 8-week-old Sprague-Dawley rats were randomly divided into three groups, an expansion only (EO) group, an expansion plus PDTC (PE) group, and a control group. The results revealed that PDTC inhibited the activity of NF-kB signaling pathway and promote one morphogenetic protein 2 (BMP-2), steocalatin (OCN) expression. Compared with the control group, the optical density (OD) value of BMP in the EO group and PE group rats increased significantly from the first day to the seventh day, and the difference was statistically significant (P<0.05). After 6.0Gy irradiation, PDTC administration group could slightly increase the total SOD level in the liver and serum of rats, and reduce the MDA level in the liver and serum, especially the effect of 60mg/kg and 90mg/kg was the most obvious.
Highlights
Nuclear transfer factor kB (NF-kB) is an important regulator of nuclear cell gene transcription
The main function of the Rel homology region is to mediate its interaction with family members of the NF-kB inhibitory protein (IkB) [14]; mediate the binding of the Rel protein to specific sequences on DNA; mediate the interaction between the Rel protein and Homologous or heterologous subunits form dimers [15]; they will carry nuclear localization signals and transfer the nuclear factor-rxB involved in activation from the cytoplasm to the nucleus [16]. kB is another protein family in the cytoplasm, and is an inhibitory factor [17]
The NF-kB inhibitors PDTC were used to study the osteolysis process of osteoclasts induced by PDTC through a series of animal experiments
Summary
Nuclear transfer factor kB (NF-kB) is an important regulator of nuclear cell gene transcription. The main function of the Rel homology region is to mediate its interaction with family members of the NF-kB inhibitory protein (IkB) [14]; mediate the binding of the Rel protein to specific sequences on DNA; mediate the interaction between the Rel protein and Homologous or heterologous subunits form dimers [15]; they will carry nuclear localization signals and transfer the nuclear factor-rxB involved in activation from the cytoplasm to the nucleus [16]. The TN receptor (TNVR) phosphorylates Ikα through action, binds to the RelB heterodimer in the matrix, and is selectively activated by the NF-kB/P100 precursor protein into the nucleus, thereby promoting Transcription of target cells. In the process of statistical analysis, weak positive, moderate positive and strong positive are treated as positive results
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