Year-end Sale % OFF 
Abstract
PurposeMalignant pericarditis is observed in 5.1–7.0% of all cases of acute pericarditis, and malignant pericardial effusion (MPE) can lead to cardiac tamponade in the later stages of cancer. Breast cancer is the second most common primary cancer associated with MPE, but the efficacy and safety of intrapericardial carboplatin (CBDCA) have never been evaluated in breast cancer. In this study, we assessed the clinical significance of intrapericardial CBDCA following catheter drainage in patients with breast cancer-related MPE.MethodsA catheter was inserted percutaneously into the pericardial space under echocardiographic guidance. After complete drainage, 150 mg of CBDCA was instilled into the pericardial space through the catheter.ResultsEight patients with symptomatic breast cancer-related MPE were treated at the Gunma Prefectural Cancer Center, between July 2010 and March 2016. One month after treatment, 100% of MPE was controlled. The median survival time from the recurrence of breast cancer until death or study follow-up was 2336 days (range 293–3937 days), while that from intrapericardial CBDCA administration until death or study follow-up was 552 days (range 35–1673 days). Grade 1 fever, nausea, hypotension, fatigue, and chest discomfort were observed in one patient (12.5%) after intrapericardial CBDCA administration.ConclusionsWe found that intrapericardial administration of CBDCA after catheter drainage appears to be safe and effective in managing breast cancer-associated MPE. As the number of patients in this study was small, further studies are warranted to determine the safety and efficacy of intrapericardial CBDCA in the management of breast cancer-related MPE.
Highlights
Malignant pericarditis is observed in 5.1–7.0% of all cases of acute pericarditis [1]
Patients with breast cancer-related symptomatic Malignant pericardial effusion (MPE) were included in the study based on the following criteria: (i) symptoms caused by MPE histologically and/or cytologically defined as a result of breast cancer, (ii) 20 years of age or older, (iii) ECOG performance status (PS) 0–3, and (iv) white blood cells ≥ 2000/mm3, hemoglobin ≥ 8.0 g/dL, Platelets ≥ 50,000/mm3, aspartate aminotransferase (AST)/ alanine amino transferase (ALT) < 5 times upper limit of normal (ULN), total bilirubin < 3 times ULN, and creatinine < 3 times ULN
Eight patients with breast cancer-related symptomatic MPE were treated at the Gunma Prefectural Cancer Center
Summary
Malignant pericarditis is observed in 5.1–7.0% of all cases of acute pericarditis [1]. Malignant pericardial effusion (MPE) can develop into cardiac tamponade, which is a lifethreatening disorder [2, 3]. Cancer Chemotherapy and Pharmacology (2019) 84:655–660 clinical significance of intrapericardial CBDCA following catheter drainage in patients with breast cancer-related MPE
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
