Abstract
The aim of this study was to report the clinicopathologic, radiographic, and immunohistochemical features of 5 cases of intraosseous xanthomas of the mandible. Clinical data were collected from records of 3 oral and maxillofacial pathology services in South America. All cases were evaluated by conventional staining with hematoxylin and eosin and immunohistochemistry including CD68 and S-100. The series included 4 females (80%) and 1 male (20%), with a mean age of 23.3 years (range, 13 to 45 years). All cases affected the mandible with predilection for the posterior region (80%). Most lesions presented radiographically as radiolucent (80%) with punched-out margin (80%) and unilocular structure (60%). Immunohistochemistry demonstrated positivity for CD68 and negativity for S-100 in xanthomatous cells in all cases. Recurrences were not observed after complete surgical removal by curettage, with a median follow-up of 27 months. The aim of this study was to report the clinicopathologic, radiographic, and immunohistochemical features of 5 cases of intraosseous xanthomas of the mandible. Clinical data were collected from records of 3 oral and maxillofacial pathology services in South America. All cases were evaluated by conventional staining with hematoxylin and eosin and immunohistochemistry including CD68 and S-100. The series included 4 females (80%) and 1 male (20%), with a mean age of 23.3 years (range, 13 to 45 years). All cases affected the mandible with predilection for the posterior region (80%). Most lesions presented radiographically as radiolucent (80%) with punched-out margin (80%) and unilocular structure (60%). Immunohistochemistry demonstrated positivity for CD68 and negativity for S-100 in xanthomatous cells in all cases. Recurrences were not observed after complete surgical removal by curettage, with a median follow-up of 27 months.
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