Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw

Sandra Bacián Martínez,Irene Rodríguez Pérez,José J Zamorano-León,Ignacio Navarro Cuéllar,Carlos Navarro Cuéllar,Roser Pujol Romanyá,Margarita Escrig De Teijeiro,Arturo Sánchez-Pérez,Antonio López-Farré,Álvaro Del Amo Fernández De Velasco,Carlos Navarro Vila,José Luis Del Castillo Pardo De Vera,María Isabel García-Hidalgo Alonso,Edurne Palacios Weiss

doi:10.3390/app11167646

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC.

Highlights

Head and neck carcinomas represent 5–7% of all cancers in the world, with epithelial neoplasms accounting for about 90% of cases
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterized by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa [2]
MRNOJ has been related to the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies [5]

Summary

Introduction

Head and neck carcinomas represent 5–7% of all cancers in the world, with epithelial neoplasms accounting for about 90% of cases. Squamous cell carcinoma is a cancer of the oral cavity and oropharynx and constitutes around 3% of all malignant tumours in the body [1]. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterized by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa [2]. It was initially described by Loos in. MRNOJ has been related to the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies [5]

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Discussion

Conclusion