Intraosseous Myofibroma of the Mandible in a 7-Year-Old Patient: A Case Report

Meshala Bala Sundram,Navasheilla Retna Retnasingam,Zuraiza Mohamad Zaini,Bahruddin Saripudin

doi:10.51407/mjpch.v27i1.117

Meshala Bala Sundram, Navasheilla Retna Retnasingam + Show 2 more

Open Access

https://doi.org/10.51407/mjpch.v27i1.117

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Abstract

Myofibroma is a benign fibrous tumour that occurs predominantly in the head and neck region followed by the trunk and extremities. However, cases occurring in the oral cavity are rare, presenting with a variable clinical appearances and wide differential diagnosis. We reported a case of a 7-year-old girl who was referred to the Department of Paediatric Dentistry, Tengku Ampuan Rahimah Hospital with a progressively enlarging painless swelling on the left posterior region of the mandible over the past 3 months. The swelling was associated with ulceration and displaced lower left first permanent molar. Radiographic investigations reported well-defined radiolucency at molar area, alveolar expansion and bone resorption of the left posterior alveolar ridge of the mandible. Complete surgical excision of the lesion was performed under general anaesthesia. Histopathological examination revealed proliferation of spindle shaped cells with biphasic growth pattern. Immunohistochemical staining showed strong positivity with vimentin and smooth muscle actin whilst negative for desmin, S100 and CD34 establishing the diagnosis of myofibroma. Although rare, myofibroma should be considered as a differential diagnosis for solitary firm swelling in the oral cavity. Histopathological examination together with immunohistochemical analysis is essential for an accurate diagnosis.

Highlights

Myofibroma is a solitary benign tumourCase report composed of myeloid cells that affects soft tissue, bone or internal organs in both children and adults [1]
Cases occurring in the oral cavity are rare with the mandible being the most common site followed by the tongue, buccal mucosa and lips [2,3]
A 7-year-old girl was referred to the Department of Paediatric Dentistry, Tengku Ampuan Rahimah Hospital with a progressively enlarging painless swelling on the left posterior region of the lower dentition over the past 3 months

Summary

Introduction

Myofibroma is a solitary benign tumourCase report composed of myeloid cells that affects soft tissue, bone or internal organs in both children and adults [1]. The tumour may present as a solitary or multicentric lesion known as myofibroma and myofibromatosis respectively Variability of clinical appearance combined with its rare nature leads to a wide differential diagnosis of the tumour. The lesion was firm in consistency, not tender, associated with buccolingual expansion of alveolar ridge along with mobile and buccally displaced lower left first permanent molar (tooth 36).

Results

Conclusion