Abstract
Tuberculosis (TB) is a chronic granulomatous disease caused by <i>Mycobacterium tuberculosis</i> infection, classified clinically as pulmonary and extrapulmonary disease, depending on the involved area. Oral manifestations by TB are uncommon, and when they occur, they usually present as superficial ulcers, patches, papillomatous lesions, or indurated soft tissue lesions. A 52-year-old man was referred for management of asymptomatic ulcerated lesion on the palate with 6-month of evolution. The main clinical differential diagnosis was squamous cell carcinoma. An incisional biopsy was performed and microscopic analysis showed intense chronic granulomatous inflammation with the presence of epithelioid cells and multinucleated giant cells, permeated by areas of necrosis. Histochemical analysis showed negativity for PAS and Grocott-Gomori and Warthin-Starry stains. However, Ziehl-Neelsen stain revealed the presence of mycobacteria. The diagnosis of TB was established, and the patient was referred to the service of infectious diseases. Although rare, TB should be included in the differential diagnosis of oral ulcers.
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