INTRAORAL PLEOMORPHIC ADENOMA: A CLINICOPATHOLOGIC STUDY OF A CASE SERIES

Abstract

Objective The aim of this study was to describe the clinicopathologic features of 21 cases of intraoral pleomorphic adenoma (PA). Study Design Between 2000 and 2016, all patients diagnosed with intraoral PA were retrieved and histopathologic slides stained with hematoxylin and eosin were reviewed. All tumors were classified histologically according to the Seifert et al. Results The palate was the most common site (42.8%), with a slight predilection for females (52.4%) and a mean age of 36.68 years. Histopathologic analyses revealed a diversity of histologic patterns. Plasmacytoid (85.7%), fusiform (38.1%), epithelioid (9.5%), mucous (19%), and oncocytic (28.5%) cells were observed, as well as fibrous (95.2%), myxoid (66.7%), and chondromyxoid (28.6%) stroma. Most tumors were encapsulated (71.5%). Squamous (57.1%), adipose (47.6%), sebaceous (14.3%), and osseous (14.3%) metaplasias were found. A small group presented with pleomorphism (23.8%), increased mitotic activity (14.3%), necrotic areas (9.5%), and capsule infiltration (4.3%). According to the Seifert's classification, most PAs were classified as subtype III (47.6%), followed by subtypes I and II (23.8%), and subtype IV (4.8%). Conclusions These results confirm the morphologic diversity of PAs. The knowledge of these detailed microscopic features is essential to a correct diagnosis and adequate treatment.