Abstract
<h3>Objectives</h3> To investigate the female mortality rate of intraoral and lip cancer in Brazil between 1980 and 2018 by anatomic location and Brazilian geographic regions. <h3>Study Design</h3> This was a descriptive ecological time series study. With secondary data based on official population estimates, the age-adjusted annual mortality rates were obtained by sex, anatomic location, and Brazilian geographic regions, and the annual percentage change was calculated. Data sets were analyzed using the Joinpoint Regression program. <h3>Results</h3> Of the 81,918 individuals who died from oral cancer during 1980 to 2018, 18,385 were women. The age-adjusted mortality rate for women was 0.47/100,000 in 1980 and 0.57/100,000 in 2018. A decrease in lip cancer mortality during 1980 to 2018 and intraoral cancer mortality in the 1980s was observed; however, in the last 2 decades, there were significant increases in female mortality, mainly due to cancer at the base of the tongue. Importantly, the northeast region presented a significant increase between 1993 and 2007 and the south and southeast regions have shown significant reductions since the 1990s. <h3>Conclusions</h3> There was a significant increase in the mortality rate due to oral cancer in Brazilian women during these 38 years.
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