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Abstract
BackgroundRemimazolam is a novel short-acting benzodiazepine characterized by metabolism independent from organ function. We report intraoperative MEP responses of two patients who underwent spine surgery under general anesthesia using remimazolam.Case presentationIn case 1, MEP monitoring was successfully performed with the use of a fixed dose of remimazolam at 0.5 mg/kg/h and remifentanil at 0.2 μg/kg/min. In case 2, an increasing dose of remimazolam from 0.5 to 1.5 mg/kg/h during the operation did not affect MEP signals. In both cases, remimazolam was titrated to maintain the values of entropy electroencephalogram (EEG) monitoring at 40–60.ConclusionsGeneral anesthesia using remimazolam and remifentanil can be a valuable alternative for spine surgery with MEP monitoring by EEG to assess the optimal dose.
Highlights
Remimazolam is a novel short-acting benzodiazepine characterized by metabolism independent from organ function
Remimazolam, a novel intravenous anesthetic, is a short-acting benzodiazepine characterized by metabolism independent of organ function [3]
Intraoperative motor evoked potentials (MEP) monitoring during spine surgery is used to detect neurologic deficits that occur due to surgical maneuvers, vascular injury, or spinal cord ischemia
Summary
Remimazolam is a novel short-acting benzodiazepine characterized by metabolism independent from organ function. * Correspondence: kondo320@hiroshima-u.ac.jp 1Department of Anesthesiology and Critical Care, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan Full list of author information is available at the end of the article surgery with MEP monitoring [4]. We report intraoperative MEP responses of two patients who underwent spine surgery under general anesthesia using remimazolam.
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