Abstract
Aim: To compare the outcome variables of these 2 commonly used anti-metabolites 5-Fluorouracil and Mitomycin-C in trabeculectomy surgeries in primary glaucoma. Material & methods: The present study was conducted on 50 eyes of 39 patients of primary glaucoma who underwent trabeculectomy over a period from January 2019 to August 2020 at Darbhanga Medical College & Hospital, Laheriasarai, Darbhanga.The patients were randomly categorized into 2 groups of 25 each. One group received 5-Fluorouracil in the dose of 50 mg/ml for duration of 4 to 5 minutes intraoperatively. The other group received intraoperative Mitomycin-C in the dose of 0.4 mg/ml applied over duration of 2 to 3 minutes. Result:Maximum complications were seen during early postoperative period in which maximum number were seen with POAG (9 cases) followed by PACG (5 cases). Late postoperative complications were seen in POAG and PACG (2 in each). Conclusion:Long-term complications may only become apparent many years later. Since our study had average period follow up of about 42 weeks, we are not able to comment on the long-term complications following the use of these drugs. In this study both 5-Fluorouracil and Mitomycin-C were found to be equally safe.
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