Intraoperative management of pediatric renal transplant recipients: An opportunity for improvement.

Abstract

Optimal organ perfusion at the time of pediatric renal transplantation is a commonly agreed upon goal. Intraoperative conditions such as fluid balance and arterial pressure determine the success of this goal. Sparse literature guides the anesthesiologist in accomplishing this. We, therefore, hypothesized that significant variability exists in the methods used to optimize renal perfusion during transplantation. A literature search was performed to assess what guidelines currently exist to optimize intraoperative renal perfusion. The intraoperative practice pathways of six large children's hospitals in North America were obtained to compare suggested guidelines. A retrospective chart review of anesthesia records was performed of all pediatric renal transplants over 7 years at the University of North Carolina. There did not appear to be agreement between the various publications in terms of standard intraoperative monitoring, specific blood pressure or central venous pressure goals, and fluid management. The practice pathways of six children's hospitals showed significant variation and lack of a consensus-driven approach. The chart review demonstrated significant variation between anesthesiologists in terms of invasive monitoring, fluid management, hemodynamic goals, vasopressor use, and analgesic choices. However, children <30 kg were significantly more likely to have arterial lines and epidural catheters placed prior to surgery. Significant variation exists across centers of expertise and even within centers of expertise with regard to the intraoperative management of pediatric kidney transplant recipients. In the era of enhanced recovery after surgery, this presents an opportunity to develop consensus on an evidence-based approach to optimize initial organ perfusion during surgery.