Intraoperative Blood Loss During Orthognathic Surgery: A Comparison of Remifentanil-Based Anesthesia With Sevoflurane or Isoflurane

Abstract

The aim of the present study was to compare the blood loss with remifentanil-based anesthesia with sevoflurane or isoflurane during orthognathic surgery. In this randomized controlled clinical trial, the patients who were scheduled for orthognathic surgery were divided into 2 groups: the sevoflurane (Sevo) group and isoflurane (Iso) group. Anesthesia was maintained using end-tidal concentrations of 1.4% sevoflurane or 0.9% isoflurane. Remifentanil was continuously infused at 0.05 to 0.5μg/kg/min to maintain the mean blood pressure (MBP) at 60 to 65mm Hg. The intraoperative blood loss was compared between the 2 groups. The Student t test for unpaired samples was used for statistical analysis. P < .05 was considered statistically significant. The study sample included 19 men and 45 women (n= 64). The mean age was 25years (range 16 to 50). The intraoperative blood loss tended to be greater in the Iso group (n= 32; 4.79 ± 3.22mL/kg) than in the Sevo group (n= 32; 4.00 ± 1.98mL/kg). However, the difference between the 2 groups was not significant. In a comparison of intraoperative blood loss during remifentanil-based anesthesia with sevoflurane or isoflurane during orthognathic surgery, no difference was observed between the 2 groups.