Abstract
BackgroundThe aim of this study was to assess the intraocular pressure and ocular biometric parameters in migraine patients during acute migraine attacks and compare them with painless period and healthy controls using a new optical biometer AL-Scan.MethodsIn this prospective, case–control study, the axial length, corneal curvature radius, anterior chamber depth, central corneal thickness, and pupil size of 40 migraine patients during acute migraine attacks and painless period and 40 age- and sex-matched healthy subjects were measured using a AL-Scan optical biometer (Nidek Co., Gamagori, Japan). All patients underwent a complete ophthalmic examination before the measurements. IOP and biometer measurements were taken at the same time of day (10:00–12:00) in order to minimize the effects of diurnal variation.ResultsThere was not a statistically significant difference in intraocular pressure between the migraine patients during acute migraine attacks (15.07 mmHg), painless period (14.10 mmHg), and the controls (15,73 ± 0,81). Also, the ocular biometric parameters did not significantly vary during the acute migraine attacks.ConclusionsFurther studies are needed to evaluate the etiopathologic relationship between intraocular pressure and ocular biometric parameters and acute migraine attack.
Highlights
The aim of this study was to assess the intraocular pressure and ocular biometric parameters in migraine patients during acute migraine attacks and compare them with painless period and healthy controls using a new optical biometer axial length (AL)-Scan
Several previous studies have reported decreased blood flow in the retina and optic nerve in migrainous patients and have demonstrated changes in the retinal and choroidal layer, no study has investigated the effect of migraine on changes in the intraocular pressure (IOP) and ocular biometric parameters in these patients [8, 9]
There were no significant differences in the mean AL, central corneal thickness (CCT), anterior chamber depth (ACD), corneal curvature radius (CCR), Corneal diameter (WtW), pupil diameter (PD), lens thickness (LT), and IOP values between those taken during pain and the headache-free interval (p > 0.05)
Summary
The aim of this study was to assess the intraocular pressure and ocular biometric parameters in migraine patients during acute migraine attacks and compare them with painless period and healthy controls using a new optical biometer AL-Scan. Cortical spreading depression (CSD), a wave of activity that propagates slowly across the brain surface, has been presumed since its original description in the 1940s to be the physiological substrate of the migraine aura [5] This has been discussed for many decades as the underlying mechanism of the aura in migraine, it is several previous studies have reported decreased blood flow in the retina and optic nerve in migrainous patients and have demonstrated changes in the retinal and choroidal layer, no study has investigated the effect of migraine on changes in the intraocular pressure (IOP) and ocular biometric parameters in these patients [8, 9]. The aim of the present study was to investigate potential differences in the IOP, the axial length (AL), corneal curvature radius (CCR), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT), corneal diameter (WtW), and pupil size between patients who have migraines during migraine attacks and the interictal period
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