Abstract
Hydrophilic gel contact lenses made of poly(hydroxyethylmethacrylate) saturated with a 1% solution of cysteine hydrochloride containing cysteine-<sup>35</sup>S were applied for 3 h onto rabbit corneas either with intact, scarified, or lime-burned epithelium. Cysteine was found to be easily released from the contact lens and the radioactivity measurements showed increased penetration of cysteine across epithelium-denuded corneas as compared with intact corneas. In lime-burned corneas the cysteine penetration was nearly five times higher in comparison with the values obtained for intact corneas. The rapid intraocular penetration of cysteine from the hydrophilic contact lenses may be useful in clinical practice to prevent the evolution of degenerative changes of eye tissues caused by alkali burns.
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