Intraocular metastasis of testicular natural killer T-cell lymphoma with diffuse retinal pigment epithelium changes.

Abstract

The purpose of this study was to report the first confirmed case of testicular natural killer T-cell lymphoma with bilateral intraocular metastasis. The author presents a chart review of a patient with testicular natural killer T-cell lymphoma metastasis to both eyes. This patient was treated with systemic chemotherapy, radiation, and intravitreal injections of methotrexate. The author identified one case of a patient with the diagnosis of bilateral metastatic natural killer T-cell lymphoma with ocular involvement treated with intravitreal methotrexate. After treatment, the patient developed diffuse widespread retinal pigment epithelium alterations in giraffe-like patterns. This represents a clinical case of a patient with primary testicular natural killer T-cell lymphoma and ocular metastasis with posttreatment retinal changes resembling bilateral diffuse uveal melanocytic proliferation.