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Abstract
Isolated rat liver cells were pulse-labeled with tritiated uridine after stimulation of transcription by hydrocortisone. The ribonucleoproteins (RNP) were revealed by ultrastructural cytochemistry and the radioactivity as visualized by high resolution autoradiography was measured by the hypothetical grain method. Immediately after labeling 70% of the nuclear radioactivity was concentrated in the dense chromatin border that also contained a large quantity of newly synthesized perichromatin fibrils. During chase, the perichromatin fibrils were shown to migrate towards the interchromatin space in parallel with the radioactivity, while labeling of the perichromatin border decreased to a very low level. The interpretation of these results is discussed in connection with our knowledge of the heterogeneous nuclear ribonucleoprotein (HnRNP) particles.
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