Abstract
Aim:To determine if intranasally administered olfactory mucosa progenitor cells (OMPCs) migrate to damaged areas of brain.Materials & methods:Rowett Nude (RNU) adult rats were injured using the Marmarou model then 2 weeks later received intranasally-delivered human OMPC. After 3 weeks, rats were sacrificed and brain sectioned. The mean distances from the human OMPCs to markers for degenerative neuronal cell bodies (p-c-Jun+), axonal swellings on damaged axons (β-APP+) and random points in immunostained sections were quantified. One-way ANOVA was used to analyze data.Results:The human OMPCs were seen in specific areas of the brain near degenerating cell bodies and damaged axons.Conclusion:Intranasally delivered human OMPC selectively migrate to brain injury sites suggesting a possible noninvasive stem cell delivery for brain injury.
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