Abstract
Transplacental infection plays a critical role in the reproductive failure induced by porcine reproductive and respiratory syndrome virus (PRRSV), yet exposure of sows and gilts to classical PRRSV generally leads to reproductive failure after 85 days of gestation. We report, for the first time, that the susceptibility of fetuses to highly pathogenic PRRSV (HP-PRRSV) is similar at 60 days and 90 days of gestation. This difference from classical PRRSV may contribute to its high pathogenicity. A field study of the HP-PRRSV vaccine in pregnant sows at mid-gestation should be considered.
Highlights
Transplacental infection plays a critical role in the reproductive failure induced by porcine reproductive and respira‐ tory syndrome virus (PRRSV), yet exposure of sows and gilts to classical PRRSV generally leads to reproductive failure after 85 days of gestation
There were no differences in the viral loads among any of the organs examined, which suggests that we successfully developed an animal model suitable for the study of transplacental infection by HP-PRRSV
Our results show that HP-PRRSV transplacentally infected fetuses in both the day 60 and 90 infected groups
Summary
Transplacental infection plays a critical role in the reproductive failure induced by porcine reproductive and respira‐ tory syndrome virus (PRRSV), yet exposure of sows and gilts to classical PRRSV generally leads to reproductive failure after 85 days of gestation. Two sows in the day 90 infected group aborted at 13 dpi and 17 dpi, corresponding to gestation days 103 and 107, respectively. At 7 dpi, significantly higher levels of virus were detected in the amnion in sows infected at day 90 of gestation than in sows infected at day 60 of gestation (Figure 2).
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