Intramyocellular Lipid Is Not Significantly Increased in Healthy Young Insulin Resistant First-Degree Relatives of Diabetic Subjects

Abstract

Insulin resistance is an early phenotypic feature of nondiabetic first-degree relatives of type 2 diabetic subjects (FDR) (1,2). While intramyocellular lipid (IMCL) is a marker of insulin resistance (3), how it develops is not completely understood. To study early defects accompanying insulin resistance, we characterized a population at high risk of type 2 diabetes (4,5). We studied young, healthy, sedentary, nonsmoking (age <45 years, BMI <36 kg/m2), normolipidemic, and normal glucose tolerant subjects. At-risk FDR subjects (14 female and 5 male) were compared with control subjects without family history of diabetes (12 female and 10 male). To test the lipid supply hypothesis, we extended previous investigations in …