Abstract
Summary The clinical implications of hemorrhagic versus nonhemorrhagic infarcts are currently unclear. Our study suggests that hemorrhage may not simply be a bystander but an active contributor to adverse left-ventricular remodeling following acute myocardial infarction. Background Patients with hemorrhagic infarcts appear to constitute a high-risk group in acute myocardial infarction (AMI). However, the clinical implications of hemorrhagic versus non-hemorrhagic infarcts are currently unclear, warranting a more systematic and mechanistic approach towards understanding the underlying consequences. The question of whether hemorrhage is simply a bystander or contributes to additional myocardial injury remains to be investigated. The purpose of the study was to artificially induce hemorrhage in normal and infarcted (but not hemorrhagic) porcine myocardium to determine whether hemorrhage, per se, worsens prior ischemic damage. Methods
Highlights
Patients with hemorrhagic infarcts appear to constitute a high-risk group in acute myocardial infarction (AMI)
Our study suggests that hemorrhage may not be a bystander but an active contributor to adverse left-ventricular remodeling following acute myocardial infarction
Firstly, hemorrhage was induced in normal porcine hearts (N=18) by direct intracoronary injection of collagenase using over-the-wire angioplasty balloon catheter advanced to mid LAD after 2nd diagonal branch; balloon inflation was maintained for 8 min
Summary
Patients with hemorrhagic infarcts appear to constitute a high-risk group in acute myocardial infarction (AMI). The clinical implications of hemorrhagic versus non-hemorrhagic infarcts are currently unclear, warranting a more systematic and mechanistic approach towards understanding the underlying consequences. The question of whether hemorrhage is a bystander or contributes to additional myocardial injury remains to be investigated. The purpose of the study was to artificially induce hemorrhage in normal and infarcted (but not hemorrhagic) porcine myocardium to determine whether hemorrhage, per se, worsens prior ischemic damage
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