Abstract
Granular cell tumors are uncommon neoplasms, and the malignant variety is even rare, making up approximately 1% to 2% of such tumors. As described in the literature of Julie C. Fanburg-Smith et al in 1996, granular cell tumors of soft tissue have been studied to clarify criteria for malignancy and prognostic factors. Six histological criteria were assessed: necrosis, spindling, vesicular nuclei with large nucleoli, increased mitotic activity (＞2 mitoses/10 high power fields at 200X magnification), high nuclear to cytoplasmic (N:C) ratio, and pleomorphism. We describe a 44-year-old woman with an intramuscular granular cell tumor in the adductor longus muscle of right thigh. The tumor size was about 7×4×3 cm in size, as measured on magnetic resonance images. To treat the patient, we performed wide excision and post- operation radiotherapy, and she had an uneventful clinical course during an 18-month follow-up period. The pertinent findings in making the diagnosis to malignant granular cell tumor are large size (＞4 cm), intramuscular location, and mitoses.
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